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Bonaz et al., 2018) that is expressed in nodose ganglion neurons (Nohr et al., 2015)

Site-specific PEGylation involves covalent attachment of polyethylene glycol (PEG) chains to predefined residues on the peptide backbone, forming a hydrophilic steric shield that reduces renal clearance, masks immunogenic epitopes, and protects against enzymatic degradation [189]

A number of factors have helped contribute to the rise of compounded drugs, including cost, availability of FDA-approved medications and the ability to customize treatments