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Semaglutide, the active compound in medications like Ozempic and Wegovy, has helped millions of patients achieve meaningful weight losswith clinical trials showing average reductions of 1522% body weight over 68 weeks

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Patients using injectable semaglutide should take levothyroxine at the same time each day, preferably on an empty stomach

Arrange a routine appointment if: Digestive side effects persist beyond 12 weeks without improvement Symptoms significantly impact your quality of life or ability to maintain adequate nutrition You're unable to tolerate the dose escalation schedule You experience unexplained weight loss beyond expected therapeutic effects New or worsening symptoms develop after the initial adjustment period Consider discontinuation and medical review if gastrointestinal symptoms are severe enough to affect your daily activities or nutritional intake