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It is known that excess lipid accumulation in non-adipose tissues is associated with higher concentrations of NEFA and TAG in the circulation, and that this is often accompanied by inflammation, oxidative stress and cellular dysfunction or death ( Reference Mattern and Hardin 53 Reference Perez-Martinez, Perez-Jimenez and Lopez-Miranda 55 )

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The spectrum of MASLD ranges from simple steatosiswhere fat accumulation causes minimal inflammationto metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH), characterized by inflammation and liver cell damage that can progress to cirrhosis

Diabetes 74 (9), 15121524