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Taken together, according to earlier research, SIRT1 can shorten the lifetime of cells through deacetylating the P53 protein, along with decreasing its transcriptional activity 126

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Energy intake Mean estimated energy intake during the ad libitum lunch was reduced by 588 and 568 kJ (16%) with liraglutide 1.8 mg ( P =0.002) and 3.0 mg ( P =0.003), respectively, compared with placebo (Figure 4)