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Of great interest, infusion of IGF-I was shown to elicit a significant (~40%) increase in cerebromicrovascular density in the adult mouse brain[343], via stimulation of HIF-1 and its downstream effector, VEGF

In cachectic cancer patients, low serum carnitine levels have been reported, and this change has been suggested to play an important contributory role in the development of cachexia

Others consider it for muscle recovery after strain or overuse

Available from: Accessed 1 Mar 2023 Brown E, Heerspink HJL, Cuthbertson DJ, Wilding JPH (2021) SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications

Faster results are safe when driven by genuine appetite suppression and reduced calorie intake rather than restrictive dieting