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A representative for the AAD tells Allure, Dermatologists care for many rare conditions, some of which have no FDA-approved treatments, [so] access to off-label prescribing is critical to care for the diverse patient populations with dermatologic disease." Paradi Mirmirani, MD, a board-certified dermatologist at Kaiser Permanente in Northern California, says she typically takes certain factorssuch as existing scientific evidence for the drug, a lack of alternative options, and the level of risk versus potential benefit to the patientinto consideration before prescribing medication for off-label use

A standardized mean difference of 0.1 or less indicates a negligible difference

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Some of these severe forms appear associated with insufficient innate immune responses, involving namely IFN- (91, 92)