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sadly, many patients develop severe fatal outcomes because of overwhelming inflammation known as cytokine storm (248, 249), that leads to ROS-mediated cell death and tissue damage typical of RNA viruses (250)
Mechanistic Target: Studied for its interaction with MC1R (melanocortin 1 receptor) to attenuate NF-kB activation in experimental models
What About NAC
The potent TGR5 agonist 6-ethyl-23(S)-methylcholic acid (INT-777) inhibits inflammation in macrophages through TGR5-mediated targeting of cAMP and NF-B signaling pathways (117)
In addition, studies on Crohn's disease patients have shown anti-inflammatory activity and an improvement in the clinical picture
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