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Dysfunction in the gut barrier (intestinal hyperpermeability or leaky gut) appears in most autoimmune conditions, potentially serving as both a trigger for initial autoimmune development and a perpetuating factor that maintains immune dysregulation

Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects

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