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( Furthermore, only one retrospective study has demonstrated an improvement in body weight with a parallel increment in T levels in 16 obese patients with uncontrolled type 2 diabetes mellitus and hypogonadism treated with dapagliflozin ( Although data on the effects of SGLT2is on HPG axis and function are poor and there are no data on testis morphology, due to their multiple metabolic effects beyond glucose control, we might presume potential SGLT2is benefit, at least indirectly through the reduction of glucotoxicity and inflammation, on male reproduction in diabetic patients with functional hypogonadism

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