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A systematic review and meta-analysis of the gut microbiota-dependent metabolite trimethylamine N-oxide with the incidence of atrial fibrillation

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Yamada et al., 2011

The human GS enzyme is a homodimer of subunits containing 474 amino acid residues, encoded by a single-copy gene ( In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the enzyme -glutamyl transpeptidase (also called -glutamyl transferase, GGT

Such effect was evidenced by increased expression of p65 NF-B, as well as enhanced IL-1 and TNF- levels in both examined brain regions