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C57BL/6J mice were housed at 27C in a controlled environment with a 12-h/12-h light/dark cycle, with free access to water and a high-cholesterol diet (HCD

Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

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Skip the next scheduled dose and resume normal dosing the following day

The results of the current randomized, double-blind, placebo-controlled clinical trial demonstrated that oral administration of l-ARG at the dose of 6 g/day for 3 months significantly improved penile erectile function assessed by IIEF-6 score and PSV evaluated at dynamic PDU in 50 male patients with vasculogenic ED, compared to 45 placebo-treated patients