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To identify mutations associated with hyperploidy using an unbiased approach, we further evaluated patients for whom both low and high ploidy samples were available, identifying SNVs present in tetraploid but not matched diploid samples, or increased in relative dose after tetraploidization (Fig

The mechanism is plausible and well-described

Mol Plant 2:344356 Queval G, Jaillard D, Zechmann B, Noctor G (2011) Increased intracellular H 2 O 2 availability preferentially drives glutathione accumulation in chloroplasts and vacuoles