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The key difference is the FDA-approved indication

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Weight-related comorbidities that lower the BMI threshold If your BMI is 27.0-29.9, you qualify for Mounjaro if you have at least one of these conditions: Cardiovascular and metabolic: Hypertension (blood pressure 130/80 mmHg or higher, or on antihypertensive medication) Dyslipidemia (LDL 130 mg/dL or higher, triglycerides 150 mg/dL or higher, or on statin therapy) Type 2 diabetes (this moves you to the diabetes pathway, which has no BMI minimum) Prediabetes (A1C 5.7%-6.4% or fasting glucose 100-125 mg/dL) Coronary artery disease History of stroke or transient ischemic attack Respiratory: Obstructive sleep apnea (diagnosed by sleep study, not just symptoms) Obesity hypoventilation syndrome Musculoskeletal: Osteoarthritis with documented functional impairment Chronic lower back pain attributable to excess weight Metabolic: Non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) Polycystic ovary syndrome (PCOS) Reproductive: Infertility related to anovulation and obesity The comorbidity must be documented in your medical record

Supporting metabolic function can help address underlying factors that make weight loss difficult, especially for individuals with metabolic resistance or weight-related health challenges

[10] Younossi, Z., Anstee, Q