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JAMA 324 , 772781 (2020)
Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1 upregulation and autophagy
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These now stripped molecules are now unstable and often referred to as free radicals. Once the process of a volatile free radical cell begins, a chain reaction is likely to cascade through hundreds of more cells until the radicalized cells eventually die or mutate
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