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These medications represent a significant advancement in obesity pharmacotherapy, with clinical trials demonstrating substantial weight loss benefits

[38] Some minor constituents, including three chalconesflavokavain A, flavokavain B, and flavokavain Chave also been identified, [38] as well as a toxic alkaloid (not present in the consumable parts of the plant [39] ), pipermethystine

While FMO3 inhibitors reduce TMAO levels, they risk adverse effects like hepatic inflammation, and individuals with FMO3 gene defects may develop trimethylaminuria (fish odour syndrome)