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These results have implications for potentially repurposing GLP-1 RAs as novel therapeutic agents in addiction medicine

One peptide, 1907, demonstrated superior FAT activity compared to the others and was pursued for additional optimization and characterization

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This apparent paradox may be explained by biased agonism ipamorelin may preferentially activate Gs/cAMP signaling pathways relevant to GH release while showing lower efficacy at beta-arrestin recruitment and downstream signaling pathways involved in appetite regulation