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Addition or removal of GABAergic spine synapses in close proximity glutamatergic synapses in dendritic spines of cortical neurons allow the control of excitatory inputs through shunting inhibition (Maccaferri, 2005) and modulation of calcium signaling by near coincident activation of the GABAergic and excitatory inputs impinging on a particular spine (Chiu et al., 2013) and it has the potential to affect processes of local, branch or dendritic segment specific computation (Prez-Garci et al., 2006)

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