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phase 3 trials are ongoing and regulatory review has not yet been completed

A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection

The primary concerns include additive blood glucose-lowering effects that may increase hypoglycaemia risk, compounded gastrointestinal side effects such as nausea and diarrhoea, and potential interference with Rybelsus absorption if not taken at appropriate intervals

Alternatively, drawing to the nearest whole unit (12 or 13 units) produces a dose of approximately 0.24mg or 0.26mg, both clinically insignificant variations from the 0.25mg target

Biomolecules 14:697