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This results in widespread allergic-type reactions, flushing, gastrointestinal distress, severe brain fog, and a worsening of autonomic dysfunction, creating a vicious, self-perpetuating cycle of inflammation and reactivity

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Exp Neurol 247:680688 Hung HC, Hsiao YH, Gean PW (2014) Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation

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The American Thyroid Association does not routinely recommend combination therapy but acknowledges it may benefit select patients with persistent symptoms despite normal TSH on levothyroxine alone