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An NIH Phase Ib study is testing semaglutide alongside buprenorphine in Opioid Use Disorder

Deamidation Asparagine and glutamine residues in peptides can undergo deamidation, a reaction where the amide group is replaced by a carboxyl group

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Without robust efficacy and safety data at that frequency, moving away from weekly schedules is off-label and unproven

Abdominal discomfort, reduced appetite, and fatigue are also common