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25 Volkov et al., who found that benefits were regardless of B12 status, discuss the possibility that patients in their study were deficient despite serum levels being within normal limits, as no other biomarker tests were carried out

One randomised, double-blind study (Badenhorst et al., 2016) found a 55.8% reduction in wrinkle volume and a 32.8% reduction in wrinkle depth after eight weeks of use

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