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Intracellular Target Access The compound was able to enter the cell models used in the foundational study and reduce the intracellular target-engagement marker 1-methylnicotinamide

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NNMT (Nicotinamide N-Methyltransferase) Inhibition Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM 4

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