Inorganic sulfate (SO 4 ) ion is a hydrophilic group
Nociplastic pain: Towards an understanding of prevalent pain conditions
Aside from hyperhomocysteinemia, C677T or A1298C MTHFR (the two genes most studied) mutations are associated with an increased risk of other conditions including cardiovascular and thromboembolic diseases such as strokes, blood clots, and heart attacks, ADHD in children, pregnancies with neural tube defects, depression, anxiety, diabetic neuropathy, glaucoma migraines, schizophrenia, and colorectal polyps
And lets admit it, who in the world would like going through emotional roller coasters, physical cramps, and loss of blood every now and then
NAC has slightly better bioavailability than standard glutathione, but it still faces challenges