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While the target population in this NMA is different from the one considered by Nuhoho et al., findings in terms of GLP-1 RAs relative efficacy and ranking are consistent between the two studies, indicating that once-daily oral semaglutide is an efficacious add-on therapy for a broad population with T2D, including people with advanced disease

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This study was small and has not been replicated

MAD has several advantages including that it is safe, effective, can be rapidly initiated, and that its beneficial effects can be observed almost immediately (7)

Prednisolone, DMARDs, or NSAIDs, were not allowed during this study period