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Some patients begin with one medication and add the second later if they hit a plateau, need stronger appetite control, or would benefit from a different mechanism

Novo CagriSema (cagrilintide + semaglutide) In REDEFINE-4 (84 weeks), CagriSema 2.4/2.4 mg delivered: 23.0% weight loss (efficacy estimand) 20.2% (treatment-regimen estimand) Missed non-inferiority vs tirzepatide Takeaway: Clinically strong, but not a category reset

Some women use peptides on an as-needed basis, while others follow a regular schedule to maintain consistent results

including federal health insurance programs like Medicare

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