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These findings position neutrophil ferroptosisorchestrated by GPX4as a mechanistic bridge between iron dyshomeostasis and loss of self-tolerance in SLE, offering a rationale for therapeutic strategies targeting neutrophil redox resilience or iron chelation in autoimmune disease

The GLP-1 group did not show an increased incidence of pancreatitis

Agents such as guanfacine (an 2A adrenergic agonist) and atomoxetine, a norepinephrine reuptake inhibitor, have demonstrated clinical efficacy in improving attention and working memory, and are used in the treatment of ADHD and post-traumatic stress disorder [223, 229]

Considering dopamines pivotal role in the brains reward system, such alterations could lead to an imbalance in dopaminergic neurotransmission 43,44