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Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion

The researchers noted that LDL increased by 0.12mmol/l with placebo but decreased by 0.14mmol/l with MK-677 within the first 12 months [16]

Chi et al