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If someone loses weight steadily with minimal side effects on semaglutide, I have no clinical reason to push them toward tirzepatide

Even the most powerful GLP-1 medication cannot fully override chronically elevated cortisol levels

GLP-1 medications solve this by using modified versions of the hormone that resist enzymatic breakdown, maintaining elevated levels for days or even a full week depending on the formulation

It's remarkably easy to underestimate calories from cooking oils, sauces, drinks, and bites while cooking, and relaxed weekend meals, and just as easy to overestimate how many calories exercise burns

Avoid using the vial in places with high dust or moisture levels, like the bathroom