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In brief, the synovial tissues were collected, washed with PBS, chopped with scissors, and soaked in PBS mix with type I collagenase (4 mg/mL) in cell culture incubators for 3 h

Fascinatingly, exendin-4 appears to stimulate cholangiocyte proliferation through the GLP-1 receptor, hereby preventing cholangiocyte apoptosis in models of bile acid-induced damage and models of ductopenic cholangiopathies (95, 96)

Preserving endogenous testosterone production capacity during the aging process warrants further investigation as a potential intervention strategy

DAMPs, Damage-Associated Molecular Patterns