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Macrophage-derived IGF-1 promotes intestinal vascular endothelial cell proliferation in vivo in neonatal mice and protects against experimental NEC To examine the role of macrophage-derived IGF-1 on intestinal vascular endothelial cell proliferation in vivo, transgenic mice that express Cre recombinase driven by the Cx3cr1 promoter were bred with mice bearing loxP sites flanking exon 4 of the Igf 1 gene, to generate mice with IGF-1-deficient macrophages (Fig

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