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Bruising or Redness at Injection Site : This is often temporary and subsides with proper injection technique

Time in tight range with glucose of 70 mg/dL to 140 mg/dL also rose from 31.9% at baseline to 38.2% at 6 months ( P = .004)

Evidence from the Major Clinical Trials The safety information for these treatments comes from extensive clinical research, including the STEP program for Semaglutide and the SURMOUNT trials for Tirzepatide

Both are dual agonists designed to produce superior weight loss compared to single-receptor medications like semaglutide , but their different receptor combinations create distinct metabolic effects, side effect profiles, and practical considerations that matter when choosing between them