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Indeed, in patient NPs, -hydroxybutyrate and, to a greater extent, acetoacetate produced a robust recovery of mitochondrial respiration parameters when combined with glucose, pyruvate, and glutamine (Figs

Ferroptosis and cuproptosis are mechanistically distinct: the former relies on Fe 2+ -dependent lipid peroxidation, whereas the latter is driven by Cu + -induced mitochondrial protein aggregation

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GO term enrichment was then assessed using the enrichGO function from the ClusterProfiler 30 R package, with the parameter universe set to include all genes detected in the bulk RNA-seq data, minGSSize set to 10, maxGSSize set to 500 and pAdjustMethod set to BH

Bruns, C., Lewis, I., Briner, U., Meno-Tetang, G