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Hydrogels are three-dimensional (3D) cross-linked networks formed by physical or chemical cross-linking of hydrophilic polymers (e.g., polysaccharide-based matrices such as chitosan, sodium alginate and cellulose derivatives), featuring high water content, good biocompatibility, and tissue-like physicochemical properties reminiscent of the natural extracellular matrix (ECM) [20,21]

This can lead to problems with ovulation for example, ovulation might happen earlier than usual (resulting in a short cycle), or be delayed (meaning a longer cycle)

But not all polyphenols are the same, and this distinction matters

J Toxicol Environ Health A 73:16651677