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The researchers plan to repeat the study using other drugs that alter excitation and inhibition whose mechanisms are better understood, says McAlonan

Metabolic reprogramming induced by glutamine metabolism Unsurprisingly, glutamine metabolism plays a critical role in tumor progression since it not only supports mitochondrial oxidative phosphorylation but also supplies metabolic intermediates for the TCA cycle, glutathione synthesis, and NEAA synthesis and simultaneously produces NADPH 157,158,159

[6] Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D

Zheng, H., Jiang, L., Tsuduki, T., Conrad, M