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The design of each phase of a clinical trial for a potential therapeutic agent is strongly influenced by the drug's mechanism of action (Fig

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However, each patients treatment plan may vary, depending on factors like: Initial weight and health status How well they respond to the medication Whether they experience significant side effects Ability to maintain healthier habits For some patients, providers may recommend continuing the medication indefinitely to maintain weight loss, particularly for those with obesity-related health conditions that improve with long-term weight management, such as diabetes, sleep apnea or high blood pressure

Modified from Ravassa et al

The 12-month animal safety data is encouraging but does not directly translate to human dosing