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The RAS is composed of two pathways that are mutually antagonistic that maintain the balance through angiotensin-converting enzyme 2 (ACE2): the classical pathway angiotensin-converting enzyme/angiotensin II/angiotensin II type 1 receptor (ACE/Ang II/AT 1 R) and the non-classical pathway angiotensin-converting enzyme 2/angiotensin- (17)/Mas receptor (ACE2/Ang-(17)/MasR)

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Issa Dahabreh reported a contract with the Patient-Centered Outcomes Research Institute and grants from the National Institutes of Health during the conduct of the study

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GPx is particularly vulnerable to the oxidative stress associated with hypertension