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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

You should contact your doctor if you experience a significant plateau or weight regain (more than 5% of lost weight) despite continued medication adherence and lifestyle efforts

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Acetyl-L-carnitine (also called ALCAR) is the acetylated form