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85,86 Conversely, hepatocyte-specific SIRT1 overexpression reduces high-fat diet-induced hepatic lipid accumulation, suggesting a protective role in hepatocytes

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"1290s weight loss efficacy in obesity seems on par and we see no reason why this can't continue in longer duration trials

An increased risk of GI side effects, including nausea, vomiting, and diarrhoea, is consistently reported: these events are attributed to the GLP-1RA component of the therapy, while an elevated risk of genital infections is associated with the SGLT2i component

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