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In March 2024, VKTXs Phase 1 clinical trial of oral pill formulation of its dual GLP-1/GIP receptor agonist, VK2735, demonstrated 3.3% placebo adj weight loss in the highest dose cohort (40mg QD, n=7) at 28-days with an excellent Gl tolerability profile

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Again, the NAC effect on nuclear Nrf2 levels was limited to the inhibition of the Zn-mediated upregulation, but no direct NAC effect on Nrf2 was observed (Figure 1e)

Not peer-reviewed