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Plus: Studies suggest that berberine and exercise may work synergistically, meaning they enhance each other's effects

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The SURPASS-2 trial directly compared the two for type 2 diabetes and found tirzepatide superior at all dose levels

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Food and Drug Administration states clearly on the Ozempic warning label that semaglutide, the active ingredient, is contraindicated in patients with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2