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Retatrutide is an investigational triple receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, producing more pronounced effects on appetite, insulin secretion, and energy expenditure than single or dual agonists

GLP-1s role as an insulinotropic incretin remained undetermined until GLP-1 (7-37), a truncated form of GLP-1, was identified by Mojsov et al

Higher baseline risk: People with diabetes already face an increased risk of gum disease and slow healing