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Patients with recurrent depression exhibit reduced hippocampal volume and hippocampal atrophy in the brain when compared to healthy controls ( Figure 2 ) (Bremner et al., 2000)

3 Melatonin: physiology and pleiotropic roles in aging Building on the age-related changes in circadian regulation, this section focuses on melatonin as a central integrative signal linking circadian timing, sleep regulation, and antioxidant defense

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In addition, NRF2 was reported to confer radioprotection to human lung fibroblasts through upregulating miR-140 expression, which is involved in the regulation of lung fibroblast self-renewal [94]

The mean BMI was approximately 23.9 kg/m2