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Cardiovascular outcome studies were not required for the approval of pramlintide, and the available preclinical data are insufficient to predict whether amylin agonism will impact cardiovascular pathophysiology in susceptible individuals

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20 Patients should be advised to seek medical attention immediately if they experience severe joint pain, severe abdominal pain, increased shortness of breath, or swelling in the legs, as these signs and symptoms could indicate the presence of a serious adverse event