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For some people, this creates a heavy, bloated, nauseated feeling that persists for hours

Stress and inflammation can cause epithelial barrier defects by directly modulating epithelial permeability and altering the intestinal mucosal properties (420)

While these results warrant cautious interpretation, especially in patients with pre-existing proliferative retinopathy, they support an overall favourable benefit-risk ratio for GLP-1RA use in advanced kidney disease, including ESKD

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Many of the older studies used outdated methodologies that would not be considered high quality by todays standards