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It is often well-tolerated in moderate doses but may have a mild laxative effect, which could be problematic for GLP-1 users already experiencing diarrhea or gastrointestinal upset

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We now demonstrate that GIPR agonist administration critically relies on Gipr expression in the hindbrain, while GIPR antagonism relies on hypothalamic Gipr expressionboth are probably neuronal populations, given that we used hSyn-driven Cre-expression for the region-specific knockout studies

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