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Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)

Large-scale randomized controlled trials meeting Western regulatory standards have not been conducted

These roles are typically limited to the intracellular milieu, where the environment is reducing, and cysteine is not oxidized to cystine

*Correspondence: Yongjie Zhang, [email protected] These authors have contributed equally to this work

Patients are encouraged to adopt a balanced diet rich in whole foods, engage in regular physical activity, and monitor their blood sugar levels consistently