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The CUPID (Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease) trial was the first gene therapy clinical study targeting SERCA2a in HF

Tissues were rapidly dissected post-mortem and either snap-frozen in liquid nitrogen and stored at -70C or fixed in 10% neutral buffered formalin for molecular analysis and histology, respectively

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It seems like a small change in weight, and yet it had dramatic benefits. The limits of diet and exercise The culture, of course, took these findings and quickly reworked them to fit existing beauty standards and narratives about personal responsibility