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The difficulty in substantiating this link partly arises from the inherent complexity of interrogating these widely-distributed systems using pharmacological approaches, compounded by observations that native GLP-1 and pharmacokinetically-optimized therapeutic GLP-1 receptor agonists (GLP-1RAs) suppress eating via divergent signalling pathways 1622

Ciarambino, T., Crispino, P

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Furthermore, the authors found that the metabolic reprogramming of border zone cardiomyocytes, induced by Nrg1/ErbB2 signaling, is crucial for their proliferation