Diabetes and stroke: Epidemiology, pathophysiology, pharmaceuticals and outcomes
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12 , 13 The most prominent molecular feature of nuclear cataract is oxidation, which is evident in the modifications occurring to the lens crystallins (and other lens proteins) and in the decreases seen in the critical cellular reducing compound glutathione
Phase II neutralizes them by covalently attaching a conjugation group (glucuronic acid, glutathione, sulfate, acetyl, methyl, or amino acid) that increases polarity, reduces reactivity, and enables transport into bile or urine
Full effects build as your body stores more B12 and uses it efficiently