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Months 2 to 3: When the Real Tissue Repair Becomes Visible By months 2 and 3, the collagen synthesis and angiogenic effects that started in week one have accumulated enough to produce structural changes in the tissue

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The copper component supports enzymes including lysyl oxidase that are critical to collagen cross-linking

Mech Dev 59(2):129140 Cox CM et al (2006) Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo

(121) identified a role for PregS in eliciting presynaptic plasticity by altering intracellular Ca 2+ via Ca 2+ -induced Ca 2+ release (CICR)